6PKC
Inhibition of Human Menin by VTP-50469
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Menin,Menin | polymer | 490 | 54867.2 | 2 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
| 2 | A, B | 5-fluoro-2-({4-[7-({trans-4-[(methylsulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N,N-di(propan-2-yl)benzamide | non-polymer | 630.8 | 2 | Chemie (OP4) | |||
| 3 | water | water | 18.0 | 572 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 457 (UniProt: O00255)
A, B: 552 - 583 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Thr 5 | Ala 5 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109734.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1261.6 | |
| All* | Total formula weight | 110996.0 |
