6G0A

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.

Summary for 6G0A

• Entry DOI: 10.2210/pdb6g0a/pdb
• Related: 6fwk
• Descriptor: DNA polymerase epsilon catalytic subunit A, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*DC)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), ... (7 entities in total)
• Functional Keywords: dna, pol2, pole, epsilon, p301r, cancer, dna binding protein
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); More
• Total number of polymer chains: 3
• Total formula weight: 145756.02

Authors

Parkash, V.,Johansson, E. (deposition date: 2018-03-16, release date: 2019-01-30, Last modification date: 2024-01-17)

• Primary citation: Parkash, V.,Kulkarni, Y.,Ter Beek, J.,Shcherbakova, P.V.,Kamerlin, S.C.L.,Johansson, E.; Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.; Nat Commun, 10:373-373, 2019; PubMed: 30670696; DOI: 10.1038/s41467-018-08114-9

Experimental method

X-RAY DIFFRACTION (2.62 Å)