6FWK

The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide

Summary for 6FWK

• Entry DOI: 10.2210/pdb6fwk/pdb
• Descriptor: DNA polymerase epsilon catalytic subunit A, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), ... (7 entities in total)
• Functional Keywords: pol epsilon, m644g, dna, complex, dna binding protein
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 6
• Total formula weight: 291283.69

Authors

Parkash, V.,Johansson, E. (deposition date: 2018-03-06, release date: 2019-01-30, Last modification date: 2019-02-06)

• Primary citation: Parkash, V.,Kulkarni, Y.,Ter Beek, J.,Shcherbakova, P.V.,Kamerlin, S.C.L.,Johansson, E.; Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.; Nat Commun, 10:373-373, 2019; PubMed: 30670696; DOI: 10.1038/s41467-018-08114-9

Experimental method

X-RAY DIFFRACTION (2.503 Å)