5VC6
crystal structure of human WEE1 kinase domain in complex with PHA-848125
Summary for 5VC6
Entry DOI | 10.2210/pdb5vc6/pdb |
Related | 5VC3 5VC4 5VC5 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA |
Descriptor | Wee1-like protein kinase, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32963.54 |
Authors | Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-03-31, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60:7863-7875, 2017 Cited by PubMed: 28792760DOI: 10.1021/acs.jmedchem.7b00996 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report