5VC5

Crystal structure of human WEE1 kinase domain in complex with PD-166285

Summary for 5VC5

Entry DOI	10.2210/pdb5vc5/pdb
Related	5VC3 5VC4 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
Descriptor	Wee1-like protein kinase, 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33192.43
Authors	Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-03-31, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60:7863-7875, 2017 Cited by PubMed: 28792760 DOI: 10.1021/acs.jmedchem.7b00996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation