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5VD9

Crystal structure of human WEE1 kinase domain in complex with RAC-IV-097, a MK1775 analogue

Summary for 5VD9
Entry DOI10.2210/pdb5vd9/pdb
Related5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VDA
DescriptorWee1-like protein kinase, 1-{6-[(1R)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, CHLORIDE ION, ... (5 entities in total)
Functional Keywordskinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight33024.99
Authors
Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citationZhu, J.-Y.,Schonbrunn, E.
Structural basis of Wee family kinase inhibition by small molecules
to be published,
Experimental method
X-RAY DIFFRACTION (1.87 Å)
Structure validation

217705

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