5SVQ

Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP

Summary for 5SVQ

Entry DOI	10.2210/pdb5svq/pdb
Related	5SVJ 5SVK 5SVL 5SVM 5SVP 5SVR 5SVS 5SVT
Descriptor	P2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (6 entities in total)
Functional Keywords	membrane protein, ion channel, antagonist state
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42175.11
Authors	Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-10-05, Last modification date: 2020-07-29)
Primary citation	Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538:66-71, 2016 Cited by PubMed: 27626375 DOI: 10.1038/nature19367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation