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5SVR

Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491

Summary for 5SVR
Entry DOI10.2210/pdb5svr/pdb
Related5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVS 5SVT
DescriptorP2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsmembrane protein ion channel antagonist state, membrane protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight41801.20
Authors
Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-10-05, Last modification date: 2020-07-29)
Primary citationMansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E.
X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538:66-71, 2016
Cited by
PubMed: 27626375
DOI: 10.1038/nature19367
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.13 Å)
Structure validation

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