5FPO

Structure of Bacterial DNA Ligase with small-molecule ligand 1H- indazol-7-amine (AT4213) in an alternate binding site.

Summary for 5FPO

Entry DOI	10.2210/pdb5fpo/pdb
Related	5FP5 5FP6 5FPD 5FPE 5FPM 5FPN 5FPR 5FPS 5FPT 5FPY
Descriptor	DNA LIGASE, 1H-indazol-7-amine (3 entities in total)
Functional Keywords	ligase, antibiotic design, protein-ligand complex, fragment screening, alternate binding site, at4213.
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	1
Total formula weight	37124.24
Authors	Jhoti, H.,Ludlow, R.F.,Pathuri, P.,Saini, H.K.,Tickle, I.J.,Tisi, D.,Verdonk, M.,Williams, P.A. (deposition date: 2015-12-02, release date: 2015-12-23, Last modification date: 2024-01-10)
Primary citation	Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740 DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation