5FP5
Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (AT222) in an alternate binding site.
Summary for 5FP5
Entry DOI | 10.2210/pdb5fp5/pdb |
Related | 5FP6 |
Descriptor | CYCLIN-DEPENDENT KINASE 2, 4-fluorobenzoic acid, ACETYL GROUP, ... (4 entities in total) |
Functional Keywords | transferase, kinase, mitosis, cell cycle, fragment screening, alternate binding site. |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34300.76 |
Authors | Jhoti, H.,Ludlow, R.F.,O'Reilly, M.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (deposition date: 2015-11-27, release date: 2015-12-09, Last modification date: 2024-01-10) |
Primary citation | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-15915, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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