5FPE
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site.
Summary for 5FPE
| Entry DOI | 10.2210/pdb5fpe/pdb |
| Related | 5FP5 5FP6 5FPD 5FPM 5FPN 5FPO 5FPR 5FPS 5FPT 5FPY |
| Descriptor | HEAT SHOCK-RELATED 70KDA PROTEIN 2, 3-AMINO-1,2,4-TRIAZOLE (3 entities in total) |
| Functional Keywords | heat shock-related protein, heat shock, chaperone, hsp70, hspa2, protein-ligand complex, fragment screening, alternate binding site, at485. |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 2 |
| Total formula weight | 85102.32 |
| Authors | Jhoti, H.,Ludlow, R.F.,Patel, S.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (deposition date: 2015-11-28, release date: 2015-12-23, Last modification date: 2024-01-10) |
| Primary citation | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
Download full validation report
