5C7M
CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT
Summary for 5C7M
Entry DOI | 10.2210/pdb5c7m/pdb |
Related | 3TUG 5C7J |
Descriptor | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C (3 entities in total) |
Functional Keywords | ligase, ubiquitin-protein ligase, ubiquitin variant, structural genomics consortium, sgc, structural genomics, ligase-signaling protein complex, ligase/signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane: Q96J02 Ubiquitin: Cytoplasm : P0CG48 |
Total number of polymer chains | 3 |
Total formula weight | 66565.05 |
Authors | Walker, J.R.,Hu, J.,Dong, A.,Wernimont, A.,Zhang, W.,Sidhu, S.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Tong, Y.,Structural Genomics Consortium (SGC) (deposition date: 2015-06-24, release date: 2016-03-16, Last modification date: 2023-09-27) |
Primary citation | Zhang, W.,Wu, K.P.,Sartori, M.A.,Kamadurai, H.B.,Ordureau, A.,Jiang, C.,Mercredi, P.Y.,Murchie, R.,Hu, J.,Persaud, A.,Mukherjee, M.,Li, N.,Doye, A.,Walker, J.R.,Sheng, Y.,Hao, Z.,Li, Y.,Brown, K.R.,Lemichez, E.,Chen, J.,Tong, Y.,Harper, J.W.,Moffat, J.,Rotin, D.,Schulman, B.A.,Sidhu, S.S. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62:121-136, 2016 Cited by PubMed: 26949039DOI: 10.1016/j.molcel.2016.02.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.03 Å) |
Structure validation
Download full validation report