5BRF
Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor HPOP-GlcN
Summary for 5BRF
Entry DOI | 10.2210/pdb5brf/pdb |
Related | 2Q2R 5BRD 5BRE 5BRH |
Descriptor | Glucokinase 1, putative, 2-deoxy-2-{[3-(4-hydroxyphenyl)propanoyl]amino}-alpha-D-glucopyranose (3 entities in total) |
Functional Keywords | transferase, hexose kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Trypanosoma cruzi (strain CL Brener) |
Total number of polymer chains | 2 |
Total formula weight | 85107.96 |
Authors | D'Antonio, E.L.,Perry, K.,Deinema, M.S.,Kearns, S.P.,Frey, T.A. (deposition date: 2015-05-30, release date: 2015-06-17, Last modification date: 2023-09-27) |
Primary citation | D'Antonio, E.L.,Deinema, M.S.,Kearns, S.P.,Frey, T.A.,Tanghe, S.,Perry, K.,Roy, T.A.,Gracz, H.S.,Rodriguez, A.,D'Antonio, J. Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. Mol.Biochem.Parasitol., 204:64-76, 2016 Cited by PubMed: 26778112DOI: 10.1016/j.molbiopara.2015.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.102 Å) |
Structure validation
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