5BRD
Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor BENZ-GlcN
Summary for 5BRD
| Entry DOI | 10.2210/pdb5brd/pdb |
| Related | 2Q2R 5BRE 5BRF 5BRH |
| Descriptor | Glucokinase 1, putative, 2-(benzoylamino)-2-deoxy-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | transferase, hexose kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Trypanosoma cruzi (strain CL Brener) |
| Total number of polymer chains | 2 |
| Total formula weight | 85019.85 |
| Authors | D'Antonio, E.L.,Perry, K.,Deinema, M.S.,Kearns, S.P.,Frey, T.A. (deposition date: 2015-05-30, release date: 2015-06-17, Last modification date: 2023-09-27) |
| Primary citation | D'Antonio, E.L.,Deinema, M.S.,Kearns, S.P.,Frey, T.A.,Tanghe, S.,Perry, K.,Roy, T.A.,Gracz, H.S.,Rodriguez, A.,D'Antonio, J. Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. Mol.Biochem.Parasitol., 204:64-76, 2016 Cited by PubMed: 26778112DOI: 10.1016/j.molbiopara.2015.12.004 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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