5BRE

Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor CBZ-GlcN

Summary for 5BRE

Entry DOI	10.2210/pdb5bre/pdb
Related	2Q2R 5BRD 5BRF 5BRH
Descriptor	Glucokinase 1, putative, 2-{[(benzyloxy)carbonyl]amino}-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	transferase, hexose kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	2
Total formula weight	85079.90
Authors	D'Antonio, E.L.,Perry, K.,Deinema, M.S.,Kearns, S.P.,Frey, T.A. (deposition date: 2015-05-30, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	D'Antonio, E.L.,Deinema, M.S.,Kearns, S.P.,Frey, T.A.,Tanghe, S.,Perry, K.,Roy, T.A.,Gracz, H.S.,Rodriguez, A.,D'Antonio, J. Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. Mol.Biochem.Parasitol., 204:64-76, 2016 Cited by PubMed: 26778112 DOI: 10.1016/j.molbiopara.2015.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation