4X5C

Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound

Summary for 4X5C

Entry DOI	10.2210/pdb4x5c/pdb
Related	4X58 4X59 4X5A 4X5B 4X5D 4X5E
Descriptor	Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	anthranilate phosphoribosyltransferase, anthranilic acids, mycobacterium tuberculosis, magnesium, tryptophan, mutation, transferase, magnesium binding, phosphoribosyl pyrophosphate
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	78272.95
Authors	Cookson, T.V.M.,Parker, E.J.,Lott, J.S. (deposition date: 2014-12-05, release date: 2015-11-25, Last modification date: 2023-09-27)
Primary citation	Cookson, T.V.,Evans, G.L.,Castell, A.,Baker, E.N.,Lott, J.S.,Parker, E.J. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54:6082-6092, 2015 Cited by PubMed: 26356348 DOI: 10.1021/acs.biochem.5b00612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation