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4X5E

Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound

Summary for 4X5E
Entry DOI10.2210/pdb4x5e/pdb
Related4X58 4X59 4X5A 4X5B 4X5C 4X5D
DescriptorAnthranilate phosphoribosyltransferase, PYROPHOSPHATE 2-, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsanthranilate phosphoribosyltransferase, anthranilic acids, mycobacterium tuberculosis, magnesium, tryptophan, mutation, transferase, magnesium binding, phosphoribosyl pyrophosphate
Biological sourceMycobacterium tuberculosis
Total number of polymer chains2
Total formula weight78983.68
Authors
Cookson, T.V.M.,Evans, G.L.,Parker, E.J.,Lott, J.S. (deposition date: 2014-12-05, release date: 2015-11-25, Last modification date: 2023-11-15)
Primary citationCookson, T.V.,Evans, G.L.,Castell, A.,Baker, E.N.,Lott, J.S.,Parker, E.J.
Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54:6082-6092, 2015
Cited by
PubMed: 26356348
DOI: 10.1021/acs.biochem.5b00612
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

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