4X5C

Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Anthranilate phosphoribosyltransferase	polymer	378	38804.8	2	UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5) In PDB	Mycobacterium tuberculosis
2	A	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	1	Chemie (PRP)
3	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	B	PYROPHOSPHATE 2-	non-polymer		176.0	1	Chemie (POP)
5		water	water		18.0	61	Chemie (HOH)

Sequence modifications

A, B: 1 - 370 (UniProt: A5U4M0)

PDB	External Database	Details
Leu 193	Arg 193	engineered mutation
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77609.7
Non-Polymers*	Number of molecules	6
	Total formula weight	663.2
All*	Total formula weight	78272.9

*Water molecules are not included.