4MZR
Crystal structure of a polypeptide p53 mutant bound to DNA
Summary for 4MZR
Entry DOI | 10.2210/pdb4mzr/pdb |
Related | 4MZI |
Descriptor | Cellular tumor antigen p53, consensus DNA sense strand, consensus DNA anti-sense strand, ... (5 entities in total) |
Functional Keywords | p53, tumor suppressor, protein-dna complex, dna binding, multidomain, oligomerization, antitumor protein/dna, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 124340.09 |
Authors | Emamzadah, S.T.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. (deposition date: 2013-09-30, release date: 2014-01-15, Last modification date: 2023-09-20) |
Primary citation | Emamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426:936-944, 2014 Cited by PubMed: 24374182DOI: 10.1016/j.jmb.2013.12.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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