4MZR
Crystal structure of a polypeptide p53 mutant bound to DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Cellular tumor antigen p53 | polymer | 237 | 27025.5 | 4 | UniProt (P04637) Pfam (PF00870) Pfam (PF07710) In PDB | Homo sapiens (human) | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 2 | K | consensus DNA sense strand | polymer | 26 | 7930.1 | 1 | |||
| 3 | L | consensus DNA anti-sense strand | polymer | 26 | 8046.2 | 1 | |||
| 4 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 358 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Met 93 | - | initiating methionine |
| Phe 121 | Ser 121 | engineered mutation |
| Gly 122 | Val 122 | engineered mutation |
| Val 135 | Cys 135 | engineered mutation |
| Val 141 | Cys 141 | engineered mutation |
| Tyr 146 | Trp 146 | engineered mutation |
| Ser 182 | Cys 182 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Pro 209 | Arg 209 | engineered mutation |
| Tyr 229 | Cys 229 | engineered mutation |
| Tyr 233 | His 233 | engineered mutation |
| Phe 234 | Tyr 234 | engineered mutation |
| Lys 235 | Asn 235 | engineered mutation |
| Phe 236 | Tyr 236 | engineered mutation |
| Val 253 | Thr 253 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
| - | Lys 292 | deletion |
| - | Gly 293 | deletion |
| - | Glu 294 | deletion |
| - | Pro 295 | deletion |
| - | His 296 | deletion |
| - | His 297 | deletion |
| - | Glu 298 | deletion |
| - | Leu 299 | deletion |
| - | Pro 300 | deletion |
| - | Pro 301 | deletion |
| - | Gly 302 | deletion |
| - | Ser 303 | deletion |
| - | Thr 304 | deletion |
| - | Lys 305 | deletion |
| - | Arg 306 | deletion |
| - | Ala 307 | deletion |
| - | Leu 308 | deletion |
| - | Pro 309 | deletion |
| - | Asn 310 | deletion |
| - | Asn 311 | deletion |
| - | Ser 313 | deletion |
| - | Ser 314 | deletion |
| - | Ser 315 | deletion |
| - | Pro 316 | deletion |
| - | Gln 317 | deletion |
| - | Pro 318 | deletion |
| - | Lys 319 | deletion |
| - | Lys 320 | deletion |
| Thr 322 | Pro 322 | conflict |
| Met 323 | Leu 323 | variant |
| Gln 340 | Met 340 | conflict |
| Arg 344 | Leu 344 | variant |
| Thr 356 | Gly 356 | conflict |
| Glu 357 | Lys 357 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 124078.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 124340.1 |
