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4MZI

Crystal structure of a human mutant p53

Summary for 4MZI
Entry DOI10.2210/pdb4mzi/pdb
Related4MZR
DescriptorCellular tumor antigen p53, ZINC ION (3 entities in total)
Functional Keywordsloop l1, tumor suppressor, antitumour protein, dna binding, antitumor protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains1
Total formula weight22595.04
Authors
Emamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. (deposition date: 2013-09-30, release date: 2014-01-15, Last modification date: 2022-12-21)
Primary citationEmamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D.
Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
J.Mol.Biol., 426:936-944, 2014
Cited by
PubMed: 24374182
DOI: 10.1016/j.jmb.2013.12.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.25 Å)
Structure validation

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