4MZI
Crystal structure of a human mutant p53
Summary for 4MZI
Entry DOI | 10.2210/pdb4mzi/pdb |
Related | 4MZR |
Descriptor | Cellular tumor antigen p53, ZINC ION (3 entities in total) |
Functional Keywords | loop l1, tumor suppressor, antitumour protein, dna binding, antitumor protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 1 |
Total formula weight | 22595.04 |
Authors | Emamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. (deposition date: 2013-09-30, release date: 2014-01-15, Last modification date: 2022-12-21) |
Primary citation | Emamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426:936-944, 2014 Cited by PubMed: 24374182DOI: 10.1016/j.jmb.2013.12.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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