4IBV
Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA
Summary for 4IBV
Entry DOI | 10.2210/pdb4ibv/pdb |
Related | 4IBQ 4IBS 4IBT 4IBU 4IBW 4IBY 4IBZ 4IJT |
Descriptor | Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 26685.91 |
Authors | Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Shakked, Z. (deposition date: 2012-12-09, release date: 2013-08-14, Last modification date: 2023-09-20) |
Primary citation | Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Rohs, R.,Shakked, Z. Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41:8748-8759, 2013 Cited by PubMed: 23863845DOI: 10.1093/nar/gkt630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report