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4IBY

Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R

Summary for 4IBY
Entry DOI10.2210/pdb4iby/pdb
Related4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBZ 4IJT
DescriptorCellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsmetal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains2
Total formula weight45678.59
Authors
Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Shakked, Z. (deposition date: 2012-12-09, release date: 2013-08-14, Last modification date: 2023-09-20)
Primary citationEldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Rohs, R.,Shakked, Z.
Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41:8748-8759, 2013
Cited by
PubMed: 23863845
DOI: 10.1093/nar/gkt630
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

217705

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