4IBU

Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA

Summary for 4IBU

• Entry DOI: 10.2210/pdb4ibu/pdb
• Related: 4IBQ 4IBS 4IBT 4IBV 4IBW 4IBY 4IBZ 4IJT
• Descriptor: Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ZINC ION, ... (6 entities in total)
• Functional Keywords: metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 8
• Total formula weight: 106060.82

Authors

Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Shakked, Z. (deposition date: 2012-12-09, release date: 2013-08-14, Last modification date: 2023-09-20)

• Primary citation: Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Rohs, R.,Shakked, Z.; Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.; Nucleic Acids Res., 41:8748-8759, 2013; PubMed: 23863845; DOI: 10.1093/nar/gkt630

Experimental method

X-RAY DIFFRACTION (1.7 Å)