4I7H

Structural basis for peroxide sensing and gene regulation by PerR from Streptococcus pyogenes

Summary for 4I7H

Entry DOI	10.2210/pdb4i7h/pdb
Descriptor	peroxide stress sensing regulator, NICKEL (II) ION, ZINC ION, ... (4 entities in total)
Functional Keywords	winged helix-turn-helix motif, oxidative stress sensing, metal homeostasis, dna, transcription
Biological source	Streptococcus pyogenes
Total number of polymer chains	2
Total formula weight	38046.94
Authors	Kumaraswami, M. (deposition date: 2012-11-30, release date: 2013-05-08, Last modification date: 2024-02-28)
Primary citation	Makthal, N.,Rastegari, S.,Sanson, M.,Ma, Z.,Olsen, R.J.,Helmann, J.D.,Musser, J.M.,Kumaraswami, M. Crystal Structure of Peroxide Stress Regulator from Streptococcus pyogenes Provides Functional Insights into the Mechanism of Oxidative Stress Sensing. J.Biol.Chem., 288:18311-18324, 2013 Cited by PubMed: 23645680 DOI: 10.1074/jbc.M113.456590 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation