4H8R
Imipenem complex of GES-5 carbapenemase
Summary for 4H8R
Entry DOI | 10.2210/pdb4h8r/pdb |
Related | 4gnu 4gog |
Descriptor | Extended-spectrum beta-lactamase GES-5, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, IODIDE ION, ... (5 entities in total) |
Functional Keywords | beta-lactamase, carbapenemase, carbapenem antibiotics, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 65296.98 |
Authors | Smith, C.A.,Vakulenko, S.B. (deposition date: 2012-09-23, release date: 2013-07-24, Last modification date: 2024-04-03) |
Primary citation | Smith, C.A.,Frase, H.,Toth, M.,Kumarasiri, M.,Wiafe, K.,Munoz, J.,Mobashery, S.,Vakulenko, S.B. Structural basis for progression toward the carbapenemase activity in the GES family of beta-lactamases. J.Am.Chem.Soc., 134:19512-19515, 2012 Cited by PubMed: 23148776DOI: 10.1021/ja308197j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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