4GDL

Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1

Summary for 4GDL

Entry DOI	10.2210/pdb4gdl/pdb
Related	4GDK
Descriptor	Ubiquitin-like protein ATG12, Autophagy protein 5, Autophagy-related protein 16-1, ... (4 entities in total)
Functional Keywords	protein-protein conjugate, protein-protein complex, ubiquitin-like protein, autophagy, e3 ligase, ubiquitin-like fold, structural protein, isopeptide bond, cytoplasm and autophagosomal membranes, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm : O94817 Q9H1Y0 Q676U5
Total number of polymer chains	3
Total formula weight	47451.65
Authors	Otomo, C.,Metlagel, Z.,Takaesu, G.,Otomo, T. (deposition date: 2012-07-31, release date: 2012-12-05, Last modification date: 2017-11-15)
Primary citation	Otomo, C.,Metlagel, Z.,Takaesu, G.,Otomo, T. Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat.Struct.Mol.Biol., 20:59-66, 2013 Cited by PubMed: 23202584 DOI: 10.1038/nsmb.2431 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.875 Å)

Structure validation