4GDK

Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1

Summary for 4GDK

• Entry DOI: 10.2210/pdb4gdk/pdb
• Related: 4GDL
• Descriptor: Ubiquitin-like protein ATG12, Autophagy protein 5, Autophagy-related protein 16-1, ... (5 entities in total)
• Functional Keywords: protein-protein conjugate, protein-protein complex, ubiquitin-like protein, autophagy, e3 ligase, ubiquitin-like fold, structural protein, isopeptide bond, cytoplasm and autophagosomal membranes, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : O94817 Q9H1Y0 Q676U5
• Total number of polymer chains: 6
• Total formula weight: 94903.30

Authors

Otomo, C.,Metlagel, Z.,Takaesu, G.,Otomo, T. (deposition date: 2012-07-31, release date: 2012-12-05, Last modification date: 2017-11-15)

• Primary citation: Otomo, C.,Metlagel, Z.,Takaesu, G.,Otomo, T.; Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.; Nat.Struct.Mol.Biol., 20:59-66, 2013; PubMed: 23202584; DOI: 10.1038/nsmb.2431

Experimental method

X-RAY DIFFRACTION (2.7 Å)