4E67

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide

Summary for 4E67

• Entry DOI: 10.2210/pdb4e67/pdb
• Related: 4E9C 4E9D
• Related PRD ID: PRD_000807
• Descriptor: Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, transferase, phosphoprotein-binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 27591.36

Authors

Sledz, P.,Hyvonen, M.,Tan, Y.S.,Lang, S.,Spring, D.,Abell, C.,Best, R.B. (deposition date: 2012-03-15, release date: 2012-10-10, Last modification date: 2023-09-13)

• Primary citation: Tan, Y.S.,Sledz, P.,Lang, S.,Stubbs, C.J.,Spring, D.R.,Abell, C.,Best, R.B.; Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.; Angew.Chem.Int.Ed.Engl., 51:10078-10081, 2012; PubMed: 22961729; DOI: 10.1002/anie.201205676

Experimental method

X-RAY DIFFRACTION (2.1 Å)