4E9D
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide
Summary for 4E9D
Entry DOI | 10.2210/pdb4e9d/pdb |
Related | 4E67 4E9C |
Related PRD ID | PRD_000810 |
Descriptor | Serine/threonine-protein kinase PLK1, 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | serine/threonine kinase, transferase, phosphoprotein binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 27951.74 |
Authors | Sledz, P.,Hyvonen, M.,Lang, S.,Stubbs, C.J.,Abell, C. (deposition date: 2012-03-21, release date: 2012-10-10, Last modification date: 2012-12-12) |
Primary citation | Lang, S.,Stubbs, C.J.,Abell, C. High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew.Chem.Int.Ed.Engl., 51:7680-7683, 2012 Cited by PubMed: 22730171DOI: 10.1002/anie.201202660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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