4E1G

X-ray crystal structure of alpha-linolenic acid bound to the cyclooxygenase channel of cyclooxygenase-2

Summary for 4E1G

Entry DOI	10.2210/pdb4e1g/pdb
Related	1DIY 3HS5 3HS6 3HS7 3QH0 3TZI
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	monotopic membrane protein, biological dimer, oxidoreductase, cox-2, n-glycosylation, membrane of er
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	144726.69
Authors	Vecchio, A.J.,Malkowski, M.G. (deposition date: 2012-03-06, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Vecchio, A.J.,Orlando, B.J.,Nandagiri, R.,Malkowski, M.G. Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE. J.Biol.Chem., 287:24619-24630, 2012 Cited by PubMed: 22637474 DOI: 10.1074/jbc.M112.372243 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation