3HS6
X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Summary for 3HS6
Entry DOI | 10.2210/pdb3hs6/pdb |
Related | 1CVU 1DDX 1DIY 1IGX 3HS5 3HS7 5COX |
Descriptor | Prostaglandin G/H synthase 2, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | oxidoreductase, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, peroxidase, phosphoprotein, prostaglandin biosynthesis |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 2 |
Total formula weight | 141382.53 |
Authors | Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. (deposition date: 2009-06-10, release date: 2010-05-12, Last modification date: 2023-09-06) |
Primary citation | Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J.Biol.Chem., 285:22152-22163, 2010 Cited by PubMed: 20463020DOI: 10.1074/jbc.M110.119867 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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