1IGX

Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

Summary for 1IGX

Entry DOI	10.2210/pdb1igx/pdb
Related	1DIY 1FE2 1IGZ
Descriptor	Prostaglandin Endoperoxide H Synthase-1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	membrane protein, fatty acid, eicosapentanoic acid, oxidoreductase, peroxidase, dioxygenase
Biological source	Ovis aries (sheep)
Total number of polymer chains	1
Total formula weight	69611.36
Authors	Malkowski, M.G.,Thuresson, E.D.,Smith, W.L.,Garavito, R.M. (deposition date: 2001-04-18, release date: 2001-12-12, Last modification date: 2023-08-16)
Primary citation	Malkowski, M.G.,Thuresson, E.D.,Lakkides, K.M.,Rieke, C.J.,Micielli, R.,Smith, W.L.,Garavito, R.M. Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. J.Biol.Chem., 276:37547-37555, 2001 Cited by PubMed: 11477109 DOI: 10.1074/jbc.M105982200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation