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3TZI

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2

Summary for 3TZI
Entry DOI10.2210/pdb3tzi/pdb
Related1CVU 1DIY 3HS5 3KRK 3MDL 3QH0
DescriptorProstaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordsoxidoreductase, n-glycosylation, monotopic membrane protein
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total formula weight141404.57
Authors
Vecchio, A.J.,Malkowski, M.G. (deposition date: 2011-09-27, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citationVecchio, A.J.,Orlando, B.J.,Nandagiri, R.,Malkowski, M.G.
Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287:24619-24630, 2012
Cited by
PubMed: 22637474
DOI: 10.1074/jbc.M112.372243
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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