4DL4
Human DNA polymerase eta inserting dCMPNPP opposite the 3'G of cisplatin crosslinked Gs (Pt-GG1).
Summary for 4DL4
Entry DOI | 10.2210/pdb4dl4/pdb |
Related | 3MR2 3MR3 3MR5 3MR6 3SI8 |
Descriptor | DNA polymerase eta, DNA (5'-D(P*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... (8 entities in total) |
Functional Keywords | cisplatin, chemoresistence, translesion synthesis, human dna polymerse eta, kinetics, molecular splint, inhibition, dna distorsion, second tls polymerase, nucleotidyl transfer reaction, pcna, transferase-dna-inhibitor complex, transferase/dna/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9Y253 |
Total number of polymer chains | 3 |
Total formula weight | 55340.47 |
Authors | Zhao, Y.,Biertumpfel, C.,Gregory, M.,Hua, Y.-J.,Hanaoka, F.,Yang, W. (deposition date: 2012-02-05, release date: 2012-05-09, Last modification date: 2023-09-13) |
Primary citation | Zhao, Y.,Biertumpfel, C.,Gregory, M.T.,Hua, Y.J.,Hanaoka, F.,Yang, W. Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta Proc.Natl.Acad.Sci.USA, 109:7269-7274, 2012 Cited by PubMed: 22529383DOI: 10.1073/pnas.1202681109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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