3SI8

Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2)

Replaces:  3MR4

Summary for 3SI8

• Entry DOI: 10.2210/pdb3si8/pdb
• Related: 3MR2 3MR3 3MR5 3MR6
• Descriptor: DNA polymerase eta, COBALT (II) ION, DNA (5'-D(*TP*A*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*C)-3'), ... (11 entities in total)
• Functional Keywords: protein-dna complex, multiple domains, three are alpha/beta fold and one of the four is helical fold, dna polymerase, dna binding, mg2+ and dntp binding, affinity tag is added and partially removed at the n-terminal end, nucleus, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9Y253
• Total number of polymer chains: 3
• Total formula weight: 57503.69

Authors

Biertumpfel, C.,Zhao, Y.,Kondo, Y.,Ramon-Maiques, S.,Gregory, M.,Lee, J.Y.,Masutani, C.,Lehmann, A.R.,Hanaoka, F.,Yang, W. (deposition date: 2011-06-17, release date: 2011-08-03, Last modification date: 2024-03-13)

• Primary citation: Biertumpfel, C.,Zhao, Y.,Kondo, Y.,Ramon-Maiques, S.,Gregory, M.,Lee, J.Y.,Masutani, C.,Lehmann, A.R.,Hanaoka, F.,Yang, W.; Structure and mechanism of human DNA polymerase eta.; Nature, 465:1044-1048, 2010; PubMed: 20577208; DOI: 10.1038/nature09196

Experimental method

X-RAY DIFFRACTION (2.15 Å)