4CXS
G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid
Summary for 4CXS
Entry DOI | 10.2210/pdb4cxs/pdb |
Related | 4CXK 4CXU |
Descriptor | ARYLSULFATASE, CALCIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase, catalytic promiscuity, directed evolution, neutral drift, sulfatase, superfamily |
Biological source | PSEUDOMONAS AERUGINOSA |
Total number of polymer chains | 2 |
Total formula weight | 121013.71 |
Authors | Miton, C.M.,Jonas, S.,Mohammed, M.F.,Fischer, G.,Loo, B.v.,Kintses, B.,Hyvonen, M.,Tokuriki, N.,Hollfelder, F. (deposition date: 2014-04-08, release date: 2015-05-13, Last modification date: 2023-12-20) |
Primary citation | Miton, C.M.,Jonas, S.,Fischer, G.,Duarte, F.,Mohamed, M.F.,van Loo, B.,Kintses, B.,Kamerlin, S.C.L.,Tokuriki, N.,Hyvonen, M.,Hollfelder, F. Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115:E7293-E7302, 2018 Cited by PubMed: 30012610DOI: 10.1073/pnas.1607817115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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