4AGD
CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-diethylaminoethyl)-5-((Z)-(5- fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide)
Summary for 4AGD
Entry DOI | 10.2210/pdb4agd/pdb |
Related | 1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AG8 4AGC 4ASD 4ASE |
Descriptor | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total) |
Functional Keywords | transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 40656.87 |
Authors | McTigue, M.,Deng, Y.,Ryan, K.,Brooun, A.,Diehl, W.,Stewart, A. (deposition date: 2012-01-26, release date: 2012-09-26, Last modification date: 2023-12-20) |
Primary citation | Mctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S. Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109:18281-, 2012 Cited by PubMed: 22988103DOI: 10.1073/PNAS.1207759109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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