1Y6B

Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor

Summary for 1Y6B

• Entry DOI: 10.2210/pdb1y6b/pdb
• Related: 1VR2 1Y6A
• Descriptor: Vascular endothelial growth factor receptor 2, N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE (3 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 1
• Total formula weight: 42153.24

Authors

Harris, P.A.,Cheung, M.,Hunter, R.N.,Brown, M.L.,Veal, J.M.,Nolte, R.T.,Wang, L.,Liu, W.,Crosby, R.M.,Johnson, J.H.,Epperly, A.H.,Kumar, R.,Luttrell, D.K.,Stafford, J.A. (deposition date: 2004-12-05, release date: 2005-06-07, Last modification date: 2024-02-14)

• Primary citation: Harris, P.A.,Cheung, M.,Hunter, R.N.,Brown, M.L.,Veal, J.M.,Nolte, R.T.,Wang, L.,Liu, W.,Crosby, R.M.,Johnson, J.H.,Epperly, A.H.,Kumar, R.,Luttrell, D.K.,Stafford, J.A.; Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.; J.Med.Chem., 48:1610-1619, 2005; PubMed: 15743202; DOI: 10.1021/jm049538w

Experimental method

X-RAY DIFFRACTION (2.1 Å)