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2XIR

Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)

Summary for 2XIR
Entry DOI10.2210/pdb2xir/pdb
Related1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X
DescriptorVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N,2-DIMETHYL-6-{[7-(2-MORPHOLIN-4-YLETHOXY)QUINOLIN-4-YL]OXY}-1-BENZOFURAN-3-CARBOXAMIDE (3 entities in total)
Functional Keywordsangiogenesis, nucleotide-binding, inhibitor, phosphorylation, receptor, transferase, transmembrane
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight36656.27
Authors
McTigue, M.,Wickersham, J.,Pinko, C.,Hong, Y.,Marrone, T. (deposition date: 2010-06-30, release date: 2011-04-13, Last modification date: 2023-12-20)
Primary citationMctigue, M.,Wickersham, J.,Marrone, T.
Discovery of the Selective Vegfr Inhibitor Pf- 00337210
To be Published,
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

217705

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