3TGK

TRYPSINOGEN MUTANT D194N AND DELETION OF ILE 16-VAL 17 COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)

3TGK の概要

• エントリーDOI: 10.2210/pdb3tgk/pdb
• 関連するPDBエントリー: 1F5R 1F7Z 1FY8
• 分子名称: TRYPSIN II, ANIONIC, PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: serine protease, complex (serine protease-inhibitor), hydrolase- hydrolase inhibitor complex, hydrolase/ hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Secreted, extracellular space: P00763; Secreted: P00974
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32400.45

構造登録者

Pasternak, A.,White, A.,Jeffery, C.J.,Medina, N.,Cahoon, M.,Ringe, D.,Hedstrom, L. (登録日: 1998-07-19, 公開日: 2001-07-04, 最終更新日: 2023-12-27)

• 主引用文献: Pasternak, A.,White, A.,Jeffery, C.J.,Medina, N.,Cahoon, M.,Ringe, D.,Hedstrom, L.; The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.; Protein Sci., 10:1331-1342, 2001; PubMed: 11420435; DOI: 10.1110/ps.44101

実験手法

X-RAY DIFFRACTION (1.7 Å)