3TGG

A novel series of potent and selective PDE5 inhibitor2

Summary for 3TGG

Entry DOI	10.2210/pdb3tgg/pdb
Related	3TGE
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38141.45
Authors	Han, S. (deposition date: 2011-08-17, release date: 2012-01-25, Last modification date: 2024-02-28)
Primary citation	Hughes, R.O.,Maddux, T.,Joseph Rogier, D.,Lu, S.,Walker, J.K.,Jon Jacobsen, E.,Rumsey, J.M.,Zheng, Y.,Macinnes, A.,Bond, B.R.,Han, S. Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg.Med.Chem.Lett., 21:6348-6352, 2011 Cited by PubMed: 21955943 DOI: 10.1016/j.bmcl.2011.08.106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation