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3TGG

A novel series of potent and selective PDE5 inhibitor2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
cGMP-specific 3',5'-cyclic phosphodiesterasepolymer32637610.21UniProt (O76074)
Pfam (PF00233)
Homo sapiens (human)cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
4D
(A)
7-(6-methoxypyridin-3-yl)-4-{[2-(propan-2-yloxy)ethyl]amino}-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2(1H)-onenon-polymer441.51Chemie (0H3)
5E
(A)
waterwater18.0179Chemie (HOH)
Sequence modifications
A: 534 - 858 (UniProt: O76074)
PDBExternal DatabaseDetails
Pro 658Arg 658engineered mutation
Ser 661-expression tag
Gln 663Asn 662engineered mutation
Phe 664Ser 663engineered mutation
Leu 665Tyr 664engineered mutation
Asn 667-expression tag
Thr 668Gln 666engineered mutation
Asn 669Arg 667engineered mutation
-His 670deletion
-Pro 671deletion
Leu 674Gln 674engineered mutation
Met 675Leu 675engineered mutation
Asn 677-expression tag
Asp 678Cys 677engineered mutation
Glu 679His 678engineered mutation
Val 681Ile 680engineered mutation
Leu 681Met 681engineered mutation
Glu 751Gln 751engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37610.2
Non-Polymers*Number of molecules3
Total formula weight531.2
All*Total formula weight38141.4
*Water molecules are not included.

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PDB entries from 2025-07-02

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