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3TGG

A novel series of potent and selective PDE5 inhibitor2

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 864
ChainResidue
AHOH7
AHIS617
AHIS653
AASP654
AASP764

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 865
ChainResidue
AHOH266
AASP654
AHOH7
AHOH60
AHOH70
AHOH111

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 0H3 A 999
ChainResidue
AHOH83
AHOH94
AHOH286
AALA545
AVAL547
AILE729
AALA767
AILE768
AGLN775
AALA779
ALEU804
AMET816
AGLN817
APHE820
AILE824

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvsNqF
ChainResidueDetails
AHIS653-PHE664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AASP654
AASP764
AHIS617
AHIS653

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149
ChainResidueDetails
AGLN817

221051

PDB entries from 2024-06-12

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