3PSD

Non-oxime pyrazole based inhibitors of B-Raf kinase

Summary for 3PSD

Entry DOI	10.2210/pdb3psd/pdb
Related	3D4Q 3PSB
Descriptor	B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]indeno[1,2-c]pyrazole (2 entities in total)
Functional Keywords	kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, zinc-finger, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P15056
Total number of polymer chains	2
Total formula weight	71196.16
Authors	Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-12-01, release date: 2011-05-18, Last modification date: 2023-09-06)
Primary citation	Newhouse, B.J.,Hansen, J.D.,Grina, J.,Welch, M.,Topalov, G.,Littman, N.,Callejo, M.,Martinson, M.,Galbraith, S.,Laird, E.R.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Woessner, R.,Randolph, N.,Lyssikatos, J.,Olivero, A. Non-oxime pyrazole based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett., 21:3488-3492, 2011 Cited by PubMed: 21536432 DOI: 10.1016/j.bmcl.2010.12.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation