3D4Q
Pyrazole-based inhibitors of B-Raf kinase
Summary for 3D4Q
Entry DOI | 10.2210/pdb3d4q/pdb |
Related | 3PSB 3PSD |
Descriptor | B-Raf proto-oncogene serine/threonine-protein kinase, (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime (3 entities in total) |
Functional Keywords | kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71182.17 |
Authors | Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2008-05-14, release date: 2008-08-19, Last modification date: 2024-02-21) |
Primary citation | Hansen, J.D.,Grina, J.,Newhouse, B.,Welch, M.,Topalov, G.,Littman, N.,Callejo, M.,Gloor, S.,Martinson, M.,Laird, E.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Woessner, R.,Randolph, N.,Lyssikatos, J.,Olivero, A. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett., 18:4692-4695, 2008 Cited by PubMed: 18676143DOI: 10.1016/j.bmcl.2008.07.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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