3PSD

Non-oxime pyrazole based inhibitors of B-Raf kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE	polymer	307	35217.6	2	UniProt (P15056) Pfam (PF07714) In PDB	Homo sapiens (human)	p94, v-Raf murine sarcoma viral oncogene homolog B1
2	A, B	6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]indeno[1,2-c]pyrazole	non-polymer		380.4	2	Chemie (SM7)

Sequence modifications

A, B: 433 - 726 (UniProt: P15056)

PDB	External Database	Details
Met 420	-	expression tag
Asp 421	-	expression tag
Arg 422	-	expression tag
Gly 423	-	expression tag
Ser 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
Gly 431	-	expression tag
Ser 432	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70435.3
Non-Polymers*	Number of molecules	2
	Total formula weight	760.9
All*	Total formula weight	71196.2

*Water molecules are not included.