3OSN
Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase Iota
Summary for 3OSN
Entry DOI | 10.2210/pdb3osn/pdb |
Related | 2ALZ 2FLL 3EPG 3EPI 3NGD |
Descriptor | 5'-D(*TP*CP*TP*(6OG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, THYMIDINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | hoogsteen base pair, protein-dna complex, y-family dna polymerase, translesion synthesis, nucleoside triphosphate, o6-methylguanine, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9UNA4 |
Total number of polymer chains | 3 |
Total formula weight | 58594.27 |
Authors | Pence, M.G. (deposition date: 2010-09-09, release date: 2010-10-20, Last modification date: 2023-09-06) |
Primary citation | Pence, M.G.,Choi, J.Y.,Egli, M.,Guengerich, F.P. Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}. J.Biol.Chem., 285:40666-40672, 2010 Cited by PubMed: 20961860DOI: 10.1074/jbc.M110.183665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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