2FLL

Ternary complex of human DNA polymerase iota with DNA and dTTP

Summary for 2FLL

Entry DOI	10.2210/pdb2fll/pdb
Related	1T3N 2AZL 2FLN 2FLP
Descriptor	DNA primer strand, DNA template strand, DNA polymerase iota, ... (6 entities in total)
Functional Keywords	dna polymerase, lesion bypass, y-family, ternary complex, p6522, replication-dna complex, replication/dna
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9UNA4
Total number of polymer chains	3
Total formula weight	52989.72
Authors	Nair, D.T.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. (deposition date: 2006-01-06, release date: 2006-12-12, Last modification date: 2023-08-30)
Primary citation	Nair, D.T.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure, 14:749-755, 2006 Cited by PubMed: 16615915 DOI: 10.1016/j.str.2006.01.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation