3HXM
Structure of an argonaute complexed with guide DNA and target RNA duplex containing two mismatches.
Summary for 3HXM
Entry DOI | 10.2210/pdb3hxm/pdb |
Related | 3DLB 3DLH 3F73 3HGE 3HJF 3HK2 |
Descriptor | Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*UP*CP*AP*CP*UP*AP*CP*CP*UP*CP*GP*U)-3'), ... (4 entities in total) |
Functional Keywords | argonaute, protein-dna-rna complex, nucleic acid binding protein-dna-rna complex, nucleic acid binding protein/dna/rna |
Biological source | Thermus thermophilus |
Total number of polymer chains | 3 |
Total formula weight | 89590.05 |
Authors | Wang, Y.,Li, H.,Sheng, G.,Patel, D.J. (deposition date: 2009-06-21, release date: 2009-10-06, Last modification date: 2023-09-06) |
Primary citation | Wang, Y.,Juranek, S.,Li, H.,Sheng, G.,Wardle, G.S.,Tuschl, T.,Patel, D.J. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461:754-761, 2009 Cited by PubMed: 19812667DOI: 10.1038/nature08434 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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